HLA-C and neoplasm: Being presented only on the surface of tumor cells by the major histocompatibility complex (MHC), which ensures their interaction with the TCR (T-cell receptor) [30], neoantigens have high immunogenic potential because they are distinguished from peptides generated by the degradation of normal proteins and thus can be recognized by the host’s immune system as non-self, which would prevent them from inducing central and peripheral immune tolerance mechanisms [31].