Though PNPLA3 had been studied since 2001, a landmark genome-wide association study in 2008 revealed PNPLA3 rs738409 as the strongest genetic risk factor for hepatic fat and inflammation across ethnicities, and refocused attention on this gene for its suspected role in NASH [3,4]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.