Some of the mutations in the JAK/STAT pathway directly increase the risk of developing well characterized autoimmune disorders like inflammatory bowel disease, psoriasis, ankylosing spondylitis, Behçet’s disease [30,31,32], RA, Sjögren syndrome, or systemic lupus erythematosus (SLE) [33,34]. The gene discussed is SOAT1; the disease is Autoimmunity.