NLRP3 and cryopyrin-associated periodic syndrome: There are several hereditary diseases with NLRP3 inflammasome involvement that are categorized as cryopyrin-associated periodic fever syndromes (CAPS) [127]; these include familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndromes (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID).