NLRP3 and atherosclerosis: Overall, NLRP3 appeared necessary for granulocyte myeloid progenitor proliferation, hypersensitivity to LPS stimulation, and most of the sustained transcriptional changes caused by a Western diet in this mouse model for the early, initiation phase of atherosclerosis, implicating the importance of NLRP3 inflammasomes for epigenetic modifications during induction of innate immune memory.