NFKBIA and B-cell chronic lymphocytic leukemia: Several studies have shown that MLN4924 inhibits NFκB signalling; in both chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, MLN4924 stabilized phosphorylated IκBα, inhibiting p65 and p50 nuclear translocation, NFκB activity and inducing apoptosis [139].