This mTORC1 activation in an AKT-independent manner is regulated by Serine/threonine-protein kinase 1 SGK1 in breast cancer, [38] and by upregulation of AXL that activates mTORC1 via Protein kinase C (PKC ) in HNSCC [22]. The gene discussed is CDK7; the disease is head and neck squamous cell carcinoma.