RTEL1 and acute myeloid leukemia: Interestingly, among the 19 genes associated with a poor outcome, APEX1 (BER), RTEL1 (HRR), and COPS6 (NER) were identified as significant essential AML genes (p = 7.9 × 10−5, 3.4 × 10−4, and 2.8 × 10−4 respectively) (Figure 1).