We observed an association between rs4968210G>A SNP (rs4968210 variant constitutes G to A substitution in intron 5 of TNF-like weak inducer of apoptosis (TNFSF12, TWEAK) transcript as well as of TNFSF12-TNFSF13 (TWE-PRIL) transcripts and the percentage of CD19+APRIL+ CLL cells. Here, CD19 is linked to B-cell chronic lymphocytic leukemia.