Similarly to our prior study [13], we observed a significant difference in genotype distribution among CLL and healthy subjects for rs3803800G>A (a missense variant of TNFSF13 Ser96Asn, exon 2, and TNFSF12-TNFSF13 (TWE-PRIL) Ser176Asn, exon 7) (χ2df = 2 = 8.56; p-value = 0.0139). This evidence concerns the gene TNFSF13 and B-cell chronic lymphocytic leukemia.