GNAO1 and epilepsy: One of the proteins that have recently emerged as an important player in epilepsy is Gαo—the major neuronal α-subunit of heterotrimeric G proteins, encoded by the gene GNAO1. Starting from 2013 [7], whole-exome sequencing in a subset of epileptic patients has resulted in an avalanche of described mutations in GNAO1 (see [8] for the most up to date review).