CD8A and neoplasm: This effect did not require CD8 T cells, as their depletion did not alter rapamycin-induced reduction in tumor weights (Figure 6B), even though rapamycin led to increased frequencies of CD8 TILs in both CON and ACA groups (Figure S8C) and an improved capacity for IFNγ production by CD8 TILs with ACA+ rapamycin (Figure S8D).