Based on the principle of abscopal radiation effects, namely that the local destruction of tumor mass at one location can induce the immune-mediated reduction of systemic, non-irradiated tumor burden, local destruction of the tumor is combined with Fms-like tyrosine kinase 3 ligand (Flt3L; a DC growth factor) injection and an activation signal, e.g., a TLR3 agonist to induce mature, immunogenic DCs that present tumor antigens [148]. Here, TLR3 is linked to neoplasm.