CD274 and hepatocellular carcinoma: On May 29, 2020, the FDA approved atezolizumab (anti-PD-L1 antibody) in combination with bevacizumab (anti-VEGF antibody) for patients with unresectable or metastatic HCC who have not received prior systemic therapy, based on the superior efficacy of this combination therapy compared to sorafenib in a phase 3 clinical trial [18].