TP53 and familial pancreatic carcinoma: Gene Set Enrichment Analysis (GSEA) demonstrated significant enrichment of E2F target, MYC targets v1 and v2, mitotic spindle, MTORC1 signaling, PI3K AKT MTOR, DNA repair, and p53 pathway gene sets to high G2M pathway score tumors in The Cancer Genome Atlas (TCGA) pancreatic cancer cohort (TCGA-Pancreatic-Adenocarcinoma [PAAD], n = 176) (Figure 1).