Indeed, high G2M score tumor was significantly associated with a higher percentage of alteration in KRAS and TP53 (Figure 3B, p = 0.003 and p = 0.026, respectively), but not with Smad4 or CDKN2A (Figure 3B, p = 0.703 and p = 0.217, respectively). This evidence concerns the gene SMAD4 and neoplasm.