Utilizing the xCell algorithm, we found that pancreatic tumors with high G2M score were significantly associated with lower fraction of CD8 T cell, and M2 macrophage, and higher fraction of T helper type 1 (Th1) cells and T helper type 2 (Th2) cells in the TCGA cohort (Figure 4A). This evidence concerns the gene CD8A and pancreatic neoplasm.