Although these findings suggest that oral intake of losartan (10 mg/kg/day) can be useful to modify the percentage of CD31+ cells and CD45+ cells in rabbit BMC reducing the incidence of fibrosis, the dose for humans must be clarified since oral losartan can induce hypotension in patients with normal arterial pressure, and the losartan dose assessed in this study is much higher than the usual therapeutic dose to control hypertension in humans. Here, PECAM1 is linked to hypertensive disorder.