CDH5 and glioblastoma: Moreover, the specific expression of VE-Cadherin (CDH5) in glioblastoma stem cells may contribute to vasculogenesis, especially under hypoxia where VE-Cadherin gene expression is upregulated, when hypoxia-inducible factor-1 or -2 (HIF-1 or -2) bind to and transactivate a VE-Cadherin promoter [58].