Following basal zinc supplementation, we identified three separate clusters with two small clusters (GP6 and hepatic fibrosis/hepatic stellate cell activation; super pathway of inositol phosphate compounds; and phosphoinositide degradation) and one large cluster (the full list of canonical pathways are listed in Supplementary Table S7) with multiple interconnected canonical pathways (Figure 3B). The gene discussed is GP6; the disease is Hepatic fibrosis.