A study showed that the utilizing of histone deacetylase (HDAC) inhibitors alone or in combination with regular chemotherapies has multiple advantages: affecting DNA repair, reorganization of the converted H3K27me3-ac epigenetic switch and improved therapeutic efficacy in the EZH2 gain-of-function (GOF) mutant DLBCL cells [67]. Here, EZH2 is linked to diffuse large B-cell lymphoma.