It is noteworthy that IL-1 down-regulates angiogenesis, as the presence of IL-1 immune-positive endothelium cells in our samples indicates that the cells might produce it in response to expansion as a protective mechanism to prevent abnormal proliferation and tumor formation via the anti-angiogenic function of IL-1 [42], as tissue expansion does stimulate the formation of new blood vessels. Here, IL1A is linked to neoplasm.