FZD6 and cancer: We observed the overexpression of isoforms of genes C3orf17, FRMD4A, FZD6, HNRNPA2B1, POSTN, PRKAA1, RRBP1 and VEGFA, and the under expression of TRIP12 isoform (ENST00000428959) in ACC patients who are not free of cancer, which is a surrogate for poor ACC outcomes (Table 2 and Fig 2).