Notably, the tumor weight was similar in control cells, cells with LP, and cells with GPC1-LP, while the tumor weight was lowest in cells with GPC1-LP (GEM), followed by cells with LP (GEM) and free GEM (Figure 5B), which suggested a better anti-tumor effect of GPC1-LP (GEM) on orthotopic PDAC mice. The gene discussed is GPC1; the disease is neoplasm.