A latest research reports that expressions of LDHC mRNA and LDH-C4 protein are significantly up-regulated in RCC, and the prognosis of patients showing a positive LDH-C4 expression is worse [19], which is consistent with our current results and previous findings that LDH-C4 is a good indicator for prognosis monitoring of breast cancer patients [26]. This evidence concerns the gene C4A and renal cell carcinoma.