We verified the reciprocal correlation between miR‐196a‐5p and NR6A1 on cell proliferation, migration, and invasion in NT‐2 and NCCIT testicular tumor cells, and proved that NR6A1 can directly bind to the CDH1 gene promoter region by recognizing the DR0 site and simultaneously recruiting the methyltransferase Dnmt1 to inhibit the expression of E‐cadherin and promote the switch of E‐cadherin expression to N‐cadherin expression. The gene discussed is NR6A1; the disease is neoplasm of testis.