Near-infrared (NIR) fluorescence imaging is a rapidly evolving technique that allows real-time detection of malignant tissue during surgery.6 This technique enhances tumor visibility as it enables the visualization of resection margins and millimeter malignant lesions that are undetectable with the naked eye or preoperative imaging techniques.7–10 SGM-101 is a tumor-targeting agent consisting of the fluorophore BM-104 covalently bound to the monoclonal antibody that targets carcinoembryonic antigen (CEA), a well-known tumor marker for CRC. Here, CEACAM5 is linked to colorectal carcinoma.