LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: Considering the crucial role of oligodendrocytes in the myelination process and in ADLD pathogenesis [13], but also the controversial role that the oligodendrocyte specific Plp-FLAG-LMNB1 mouse model demonstrated in relation to the complexity of ADLD clinical phenotype and oligodendrocyte dysfunction [47], it is possible that the role of the astrocyte alteration might be pivotal in determining oligodendrocyte dysfunction, via cellular signaling mechanisms.