Indeed, our results related to cellular morphology show that severe ultrastructural nuclear alterations, such as misshaped and folded nuclei, are present in ADLD patients’ primary dermal fibroblasts, and both in control primary dermal fibroblasts and in the astrocyte cell line overexpressing Lamin B1, but not in the oligodendrocyte cell line overexpressing Lamin B1. This evidence concerns the gene LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy.