WNT5A has dual effects on the tumor microenvironment; it can promote inflammation and chemotaxis of immune cells through activation of the ROR1/Akt/P65 pathway, as well as stimulating the TLR/MyD88/p50 pathway in myelomonocytic cells, to promote synthesis of the anti-inflammatory cytokine, IL-10 [44]. Here, ROR1 is linked to neoplasm.