Finally, given that REV‐ERBα is a key chromatin regulator (Kim et al, 2018) linking circadian rhythms with metabolism (Cho et al, 2012; Zhang et al, 2015), inflammation (Pariollaud et al, 2018), and cardiac surgery outcomes (Montaigne et al, 2018) and has tumor suppressor (Sulli et al, 2018) and anti‐viral properties (Zhuang et al, 2019), the recognition that REV‐ERBα expression can be boosted more than 10‐fold by 18°C exposure will be of significance for the development of novel strategies that broaden the applications of controlled deep hypothermia. This evidence concerns the gene NR1D1 and neoplasm.