Notably, in metastases CRYM mRNA expression was significantly downregulated (Chandran cohort: 3.21‐fold, P < .0001; Varambally cohort: 3.10‐fold, P = .0007) and THRB (TRβ) mRNA levels were concomitantly overexpressed (Chandran cohort: 1.89‐fold, P = .0002; Varambally cohort: 2.11‐fold, P = .045) compared to primary PCa tumor tissue (Figure 3C). The gene discussed is THRB; the disease is neoplasm.