Among all variables evaluated in the univariate Cox regression analysis (Table 2), age, cognitive impairment, C-reactive protein, LDH, and GNRI moderate-severe risk category (HR 8.571 [CI 1.096–67.031] p = 0.041) were associated with in-hospital death, while albumin, body mass index, and PaO2/FiO2 ratio showed a protective role. This evidence concerns the gene ALB and Cognitive impairment.