Huth et al. [67] used a targeted proteomic approach, grouping 47 biomarkers into 19 pathways, to illustrate the contribution of different pathways to the percentage of explained variance in incident T2D, showing the insulin-like growth factor (IGF)/IGF-binding proteins (IGFBP) system and adipose-derived hormone pathways, as the largest contributors to T2D risk. This evidence concerns the gene IGF1 and type 2 diabetes mellitus.