In Europe, ADPKD affects about one per 800-1000 people and accounts for 6-10% of end-stage renal disease (ESRD) patients [1-3]. ADPKD is characterized by mutations in polycystic kidney disease 1 (PKD1), polycystic kidney disease 2 (PKD2) and glucosidase II alpha subunit (GANAB) genes that increase the cyclic adenosine monophosphate (cAMP) intracellular levels and upregulate the mammalian target of rapamycin receptor (mTOR). Here, PKD1 is linked to autosomal dominant polycystic kidney disease.