AGER and acute respiratory distress syndrome: Here, we review the recent studies which have sought to address this gap in knowledge with the majority showing ARDS results in increases to primarily inflammatory markers with upregulation of genes also normally seen in an inflammatory response. Increases have been seen with IL-6, IL-1, histones, and receptor for advanced glycation end-products (RAGE) levels all of which have clinical significance and present the possibility of expanded treatment options [2].