In parallel, Hu et al. 95discovered disulphiram (a drug used to treat alcohol addiction) and Bay 11‐7082 (a previously identified NF‐κB inhibitor) to potently inhibit GSDMD pore formation in liposomes and inflammasome‐mediated pyroptosis via covalently modifying Cys191/192 (human/mouse) of GSDMD. Here, GSDMD is linked to Addictive alcohol use.