In agreement, several studies demonstrated that gasdermin family members contribute to septic shock and autoinflammatory diseases, including multiple sclerosis (MS), systemic sclerosis (SSc), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), familial Mediterranean fever (FMF) and type 1 diabetes (T1D; Table 2). This evidence concerns the gene GSDMA and familial Mediterranean fever.