Finally, we systematically assessed several therapeutic efficacy biomarkers of ICB, including microsatellite instability (MSI) status, TMB, neoantigen burden and PD‐L1‐positive rate, in SCCE with available whole‐exome sequencing data and pathologic analyses and revealed the possibility of effective immunotherapy in some SCCE patients. Here, CD274 is linked to cervical small cell carcinoma.