Notably, fibrinogen‐like protein 1 (FGL1), a ligand of LAG3,19 was significantly upregulated in the tumor tissues of some patients showing modest infiltration of leucocytes (patients 4, 5, and 7), indicating that FGL1‐LAG3 signalling might be an inherent mechanism of the immune inhibition of SCCE. This evidence concerns the gene FGL1 and neoplasm.