Chi-square results showed that there were significant relationships between the expression of IL-36 and certain clinical parameters, such as liver cirrhosis, metastasis, HBV infection, serum AFP level, and surgical intervention (P<0.05); but no tight correlation was found between expression level of IL36 and other clinical parameters, likely age, gender, TNM stage and tumor size (P>0.05) (Table 2).The association between clinical pathological features and prognosis were further analyzed by univariate and multivariate analyses. This evidence concerns the gene AFP and neoplasm.