IL22 and Psoriasiform dermatitis: IL36 has been demonstrated as a pivotal mediator of skin inflammation and could induce the expression of some pro-inflammatory cytokines such as IL12, IL23, IL22, IL-36R signaling is also essential for the development of psoriasiform dermatitis in response to environmental cues such as Imiquimod through the pathogenic IL-23/IL-17/IL-22 axis 10.