CD4 and hepatocellular carcinoma: Tregs are important immunosuppressive cells 28, and Th9 cells represent a unique subset of CD4+ T Cells endowed with the ability to eradicate advanced tumors 29, these could become potential mechanisms for IL36 in CD4+ T cells to induce the antitumor effector, and may explain higher expression of IL36 in HCC with better prognosis.