For example, IL36 gene therapy has therapeutic effects on the regression of tumor masses in fibrosarcoma mouse model 24, IL-36α could be applied as a novel predictor of prognosis and a potential therapeutic drug for colorectal cancer 25, and IL-36γ could play important role in the physiologic immune response to colorectal cancer by sustaining inflammation within the tumor microenvironment 26. This evidence concerns the gene IL36G and fibrosarcoma.