CYP2E1 and hepatocellular carcinoma: In HCC HepG2 cells, the non-seed region of nuclear miR-552 (AACAGAUUGGUCA) binds to the cruciform structure of the CYP2E1 promoter and inhibits transcription of CYP2E1, while the seed region of cytoplasmic miR-552 (GUGGACAA) can bind the 3' UTR of CYP2E1 mRNA and thus inhibit translation of CYP2E1 38.