However, in many species like rat, rabbit and human, PHLDA1 was a needy role for Fas/FasL expression, and inhibited Akt pathway in various tumor behaviors such as apoptosis, autophagy, epithelial to mesenchymal transition (EMT) and endoplasmic reticulum (ER) stress 30-33, 35, 39-41. This evidence concerns the gene PHLDA1 and neoplasm.