A sensitivity analysis including only the 55 patients with microbiologically confirmed infection showed significant AUC [95% CI] for the CRP (0.80 [0.65–0.96]) and the platelet/d-dimer ratio (0.73 [0.59–0.87]), and also for the NLR (0.71 [0.52–0.86]) and LDH (0.73 [0.55–0.90]) (Supplementary Table 3). The gene discussed is CRP; the disease is infection.