IL6 and Venous thrombosis: While IL-6 has been associated with the resolution of thrombi through macrophage recruitment and the induction of proteolytic enzymes28, other studies have demonstrated an association between the development of deep venous thrombosis and the inflammatory injury of vascular endothelial cells caused by the imbalance of cytokine expression and, particularly, IL-6 was significantly upregulated in clinical and experimental studies of deep venous thrombosis, and blocking IL-6 in mice with neutralizing antibodies inhibited the formation and development of thrombosis29.