LMNB2 and acquired partial lipodystrophy: No pathogenic single-nucleotide variants in LMNB1 have been reported, although genomic duplications incorporating LMNB1 cause adult-onset leukodystrophy (MIM 169500).3 For LMNB2, a homozygous missense variant in a family with progressive myoclonic epilepsy and ataxia has been described.4 Enrichment of heterozygous LMNB2 variants in acquired partial lipodystrophy patients has also been reported.5