No pathogenic single-nucleotide variants in LMNB1 have been reported, although genomic duplications incorporating LMNB1 cause adult-onset leukodystrophy (MIM 169500).3 For LMNB2, a homozygous missense variant in a family with progressive myoclonic epilepsy and ataxia has been described.4 Enrichment of heterozygous LMNB2 variants in acquired partial lipodystrophy patients has also been reported.5 Here, LMNB2 is linked to Progressive myoclonic epilepsy.