The most common grade ≥ 3 adverse drug reactions reported in at least 2 patients were diarrhoea (6.36%), nausea (5.45%), decreased appetite (3.64%), vomiting, abnormal hepatic function, liver disorder (each 2.73%), interstitial lung disease, drug-induced liver injury, increased alanine aminotransferase (ALT) and decreased platelet count (each 1.82%). The gene discussed is GPT; the disease is interstitial lung disease.