Serious adverse drug reactions were noted in 7 patients (15.22%), which included decreased appetite, dehydration, cerebral infarction, myocardial infarction, pneumonia aspiration, nausea, cholecystitis acute, liver disorder, pyrexia, increased ALT, increased gamma-glutamyltransferase and increased blood alkaline phosphatase in 1 patient each (2.17%). This evidence concerns the gene GPT and Fever.