As observed in the Ewing sarcoma model, the efficiency of the AdCas9_BA editing vector was also associated with a robust decrease in the number of Ki67+ cells (82% vs 17%, p < 0.001) and an increase in apoptotic cells (2.5% vs 10%, p < 0.05) (Supplementary Fig. 6h, i). This evidence concerns the gene MKI67 and Ewing sarcoma.