RGS5 and pancreatic neoplasm: Fibroblasts (COL1A1+) were clustered into two different types: PDGFRA+ fibroblasts exhibit strong expression of various cytokines and chemokines, including CXCL12, IL6, CXCL14, CXCL1, and CXCL2, which is similar to iCAFs described by Öhlund D et al. in a pancreatic cancer model12; RGS5+ fibroblasts have characteristics that are similar to myo-cancer-associated fibroblasts (mCAFs) (Fig. 3a, b).