Although we found decreased endocrine toxicity in older patients, a previous study specifically looking at patients with melanoma receiving ICI therapy showed the opposite trend, of increasing incidence of autoimmune endocrinopathy with age.21 This may reflect disease-specific effects of ICI therapy or other factors inherent to the demographics of the study populations including the fact that many patients in the previous study had received ipilimumab prior to PD-1 inhibition. This evidence concerns the gene PDCD1 and melanoma.