ACTN2 and muscular dystrophy: MnM (CG14964) seems to be a hub gene within the interaction network of sarcomere genes, as shown in Fig. 3A. Four interaction partners of MYOM2 are known to carry mutations causing cardiomyopathies (MYH7, ANKRD1, ACTN2 and TTN), whereas two are known to cause muscular dystrophy (DYSF and CAPN3).