In humans, there are, besides MYOM2, which is specifically expressed in the heart and skeletal muscle, two other myomesin genes, namely MYOM1 and MYOM3. However, this apparent redundancy in myomesins does not result in a buffering effect per se, which can be seen, for example, in the genomics of arthrogryposis (Pehlivan et al., 2019). The gene discussed is MYOM2; the disease is arthrogryposis.