In CN and AD, we found trend level sTREM2 x ApoE4 interactions for rates of change in ADAS13 (CN: F = 3.78, p = 0.053, Cohens f2 = 0.135; AD: F = 3.23, p = 0.07, Cohens f2 = 0.230), but no effects on rates of change in ADNI-MEM (CN: p = 0.95, AD: p = 0.22). This evidence concerns the gene APOE and Alzheimer disease.