PITX2 and atrial fibrillation: Furthermore, from the perspectives of risk genes of AF and neurodegenerative diseases, previous GWASs for AF identified two loci at PITX2 gene-rs6843082 and C9orf3 gene-rs7026071, which were also associated with a risk of ALS (p = 0.0138 and p = 0.049, respectively) [54–56].