HMGCR and posterior cortical atrophy: Noteworthy, the three PCa cell lines where we reported a clear VPA/SIM synergistic antiproliferative and pro-apoptotic effect (PC3, 22Rv1, DU145), expressed high baseline protein levels of AMPK, HMGCR and YAP compared to EPN and LNCaP cells (Supplementary Fig. S5D), again suggesting that the mechanism by which VPA and SIM synergized requires the coordinated activation/addiction of/to these pathways.