FLT3 and acute myeloid leukemia: The benchmark response rates to second and even potentially third FLT3i sequential exposure, to a second-generation FLT3i in patients previously exposed to another prior second-generation FLT3i, and to single-agent FLT3i versus FLT3i-based combinations in R/R FLT3 AML, are important clinical practice and future trial development questions that remain poorly defined.