AKT1 and gastric cancer: Interestingly, similar to our study, a similar study based on the GSE34715 dataset [11] also showed that PI3K/AKT signaling pathway was affected by WTX overexpression in HEK293 cells (Fig. 3c and Fig. S2b-c), suggesting that the PI3K/AKT pathway may be the major downstream signaling pathway of WTX in GC cells.