Hereditary transthyretin (ATTRv) amyloidosis is caused by TTR mutations that decrease the stability of the TTR tetramer, whereas acquired (wild-type) transthyretin (ATTRwt) amyloidosis is related to tetramer destabilization with increasing age and possibly also to a decreased protein aggregate clearance in the elderly [6, 7]. The gene discussed is TTR; the disease is prealbumin measurement.