DNAJC5 and malaria: The results of this study show that geographical factors and the local epidemiological situation may affect selection and distribution of specific P. falciparum alleles and haplotypes, as was the case for the three selected malaria vaccine candidate antigens, sera5, eba-175, and csp. For sera5, the increased prevalence of ORII allele among individuals with parasite density above 5000 parasites/μL, in symptomatic individuals, and in children < 5 years strongly implicate this allele as a target of immune selection pressure.