In contrast, type 2 luminal cells exhibited higher expression of PCa suppression-related genes, Latexin (LXN) and Secretory Leukocyte Peptidase Inhibitor (SLPI), the loss expression of which were usually detected in PCa and associated with negative prognosis of PCa patients (Supplementary Fig. 3B, E) [27, 28]. The gene discussed is SLPI; the disease is posterior cortical atrophy.